Peptidomics in Drug Development

Traditionally, the specificity of proteases is determined using standard or optimized peptide libraries containing small recognition sites or, for de novo screening, phage display libraries (Richardson, 2002). These techniques may prove to be useful as a first screening approach. However, they are insufficient to predict the outcome of inhibiting a proteolytic activity in an in vivo situation. 

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Schulz-Knappe P, Zucht HD, Schrader M. Differential peptide display. In Gaenschirt D, Harms F, Rohmann S, Schulz-Knappe P, editors. Peptidomics in Drug Development. Aulendorf, Germany Editio Cantor, 2005 33-35. 

Ganshirt, D., Harms, F., Schuiz-Knappe, P. (2005). Peptidomics in Drug Development. Editio Cantor Verlag, Aulendorf. 

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