Peptide transporter family

W. N. Fischer. B. Andre, D. Rentsch, S. Krolkiewicz, M. Tegeder, K. Breitkreuz, and W. B. Frommer, Amino acid transport in plants. Trends Plant Sci. 3 188 (1998), H. Y. Steiner, W. Song, L. Zhang, F. Naider, J. M. Becker, and G. Stacey, An Arahidopsis peptide transporter is a member of a novel family of membrane transport proteins. Plant Cell 6 189 (1994). 

In the intestine following peptide transporters have been identified PEPT1, peptide/histidine transporter PHT1, PHT2 and the peptide transporter PT1 (Herrera-Ruiz et al. 2001). PT1 belongs to the cadherin family ... 

Table 7. Peptide transporter (PEPT) nucleoside transporter families. ...

Eukaryotic cells utilize an efficient transport system that delivers macromolecules fast and secure to their destination. In the case of the small GTP binding proteins of the Ras family the modified C-terminus seems to be sufficient for addressing the polypeptide to its target membrane (in the case of Ras itself the plasma membrane). Lipopeptides with the C-terminal structure of N-Ras (either a pen-tamer with a C-terminal carboxymethylation and farnesylation or a heptapeptide with a palmitoyl thioester in addition) and a N-terminal 7-nitrobenz-2-oxa-l,3-diazolyl (NBD) fluorophore were microin-jected into NIH3T3 fibroblast cells and the distribution of the fluorophore was monitored by confocal laser fluorescence microscopy. Enrichment of the protein in the plasma membrane was efficient only for peptides with two hydrophobic modification sites, while the farnesylated but not palmitoylated peptide was distributed in the cytosol.1121... 

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