Peptide tags, ABPs

Another example of an affinity tag for ABPs is short stretches of peptide nucleic acids (PNAs). This method was used to create probes in which the structure of the probe is coded by the PNA tag. The tag also serves as a way to purify the probe labeled targets through direct hybridization to a DNA containing chip. " Finally, there have been a number of examples of the use of small molecule probes that have been directly attached to a solid support. In this case, the tag is the resin bead. While this is not optimal for covalent probes as it would require a method to cleave the probe from the resin, it has proven to be valuable for use in isolation of kinase targets using reversible probe bound resins. ... 

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