Peptide-substrate interaction, combinatorial

In the 1990s, an alternative to the iterative approach for the identification of selective peptide receptors was pioneered by Still [5]. Mirroring developments in medicinal chemistry, a combinatorial approach was used to prepare libraries of possible receptor structures, which could then be screened to identify a receptor for a given substrate. Twenty years later, combinatorial methods are clearly regarded as useful tools to optimize designs, facilitate access to new hosts, and ultimately aid in the understanding of host-guest interactions. 

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