Peptides, metal complexes

Keywords a-Cyanoliydrin, a-Aminonitrile, Hydrogen cyanide. Acetone cyanohydrin, TMSCN, Lewis acid. Cyclic dipeptide. Peptide-metal complex, Strecker synthesis... 

Pentan-2-amme, 4.4 -(ethyleiiediimino)bis-complexcs structure, 25 Peptides metal complexes deuterium exchange, 426 hydrolysis, 428, 440 Peyrone s reaction, 17 Peyrone s salt configuration, 17 history, 3 Pfeifier, Paul, 1.5 Pfeiffer effect, 26... 

To further investigate the metal coordination properties of Fc-peptides, metal complexes of Fc GlyOH 20 and Fc-GluOH 22 were synthesized in aqueous... 

Dowex 1-X2 0.6 0.65 Strongly basic anion exchanger with S-DVB matrix for separation of small peptides, nucleotides, and large metal complexes. Molecular weight exclusion is <2700. 

Grill, E., Winnacker, E.-L. Zenk, M.H. (1985). Phytochelatins The principal heavy-metal complexing peptides of higher plants. Science, 230, 674-6. 

Bob s research interests and knowledge across chemistry were great. Throughout his career he retained an interest in biomimetic chemistry, specifically the study of metal ion-promoted reactions and reactions of molecules activated by metal ion coordination. His early interests in carbohydrate chemistry inspired him to study metal ion catalysis of both peptide formation and hydrolysis as well as studies in inorganic reaction mechanisms. He was particularly interested in the mechanisms of base-catalyzed hydrolysis within metal complexes and the development of the so-called dissociative conjugate-base (DCB) mechanism for base-catalyzed substitution reactions at inert d6 metal ions such as Co(III). 

The kinetics and mechanisms of substitution reactions of metal complexes are discussed with emphasis on factors affecting the reactions of chelates and multidentate ligands. Evidence for associative mechanisms is reviewed. The substitution behavior of copper(III) and nickel(III) complexes is presented. Factors affecting the formation and dissociation rates of chelates are considered along with proton-transfer and nucleophilic substitution reactions of metal peptide complexes. The rate constants for the replacement of tripeptides from copper(II) by triethylene-... 

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