Peptide clearance mechanisms

Camacho IE, Semeels L, Spittaels K, Merchiers P, Dominguez D, De Strooper B (2004) Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide. J Neurosci 24 10908-10917. 

Absorption of the protein and peptide molecules delivered to the respiratory tract competes against various other clearance mechanisms. When a particle containing a therapeutic substance is deposited in the... 

Peptide and protein therapeutics often have short in vivo half-lives due to proteolysis and renal clearance. Carbohydrate receptor clearance mechanisms and immune system responses can also contribute to a reduction in half-life. PEGylation of proteins does the following ... 

An important validation of the mice that overexpress human mutant 3APP as a platform for testing therapeutics targeting 3-peptide deposition has been provided by the Elan company, using their PDAPP mouse [146]. Immunization of the mice, either at an early age or after plaques had formed, resulted in clearance of immunoreactive plaques and peptide from the subjects brains. Although the elucidation of the mechanism explaining... 

A further interesting point comes from the comparison of the in vivo data with the other ligand substitution results in general. The in vivo half-lives listed are comparable with the rate data of the equatorial substitution and might suggest that the mechanisms responsible for the uptake/clearance of the radiopharmaceuticals, be they protein, peptide, or DNA interactions or innersphere redox reactions, might indeed be associated therewith. This is, however, just an observation and surely requires much more research to be well understood. 

Rogers J, Strohmeyer R, Kovelowski CJ, Li R (2002) Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide. Glia 40 260-269. 

MECHANISM OF ACTION of Af, immunotherapy Immunization with Af and passive administration of anti-A/S antibodies have both shown profound efficacy by many criteria in APP transgenic mice. What these results leave unanswered, however, is precisely how the antibodies are achieving their effect. Do they stimulate microglial phagocytosis of existing plaques (121), or do they achieve clearance by sequestering free Af in plasma, CSF, and brain extracellular fluid (122,151). Experiments from maty laboratories continue to attempt to address this question, as it may provide insight into the nature of Af peptide accumulation and toxicity and help direct future therapeutic approaches. 

Kuhnke, D. et al. (2007) MDRl-P-glycoprotein (ABCBl) mediates transport of Alzheimer s amyloid-beta peptides — implications for the mechanisms of Abeta clearance at the blood—brain barrier. Brain Pathology, 17 (4), 347-353. 

The renal clearance parameters of the peptides in the perfused rat kidney are presented in Table 5.1. Renal clearances of the peptides corrected for protein binding in the perfusate approached the glomerular filtration rate. Thus, the analysis of elimination mechanisms in perfused rat kidney confirmed that all agents under study were ehminated in the kidney, predominantly by glomerular filtration. 

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