Pepsinogen excretion

Representative papers are Farnsworth EB, Speer E, Alt HL. The quantitative determination of pepsin-like substance in the urine of normal individuals and of patients with pernicious anemia. J Lab Clin Invest 31 1025-1028, 1946 Janowitz HD, Levy MH, Hollander F. The diagnostic significance of urinary pepsinogen excretion in diseases of the gastrointestinal tract. Am J Med Sci 220 679-682, 1950. 

Mirsky lA, Kaplan S, Broh-Kahn RH. Pepsinogen excretion (uropepsin) as an index of influence of various life situations. Res Publ Assoc Nerv Ment Dis 29 62 -646,1950, p 640. 

Pepsinogen appears to be excreted in characteristic amounts by each individual. The range in excretion of pepsinogen by normals was found to be from 0 to 136 units per hour.32 The acid phosphatase activities of male urines show a range of 5 to 310 units. Women excrete less, 5 to 70 units.33... 

Source Adapted from Hirschowitz BI, Streeten DHP. Significance of increased urinary pepsinogen (uropepsin) excretion during ACTH administration and in duodenal ulcer patient. J Lab Clin Med 50 210, 1957. 

Anson ML, Mirsky AE. The estimation of pepsin with hemoglobin. 7 Physiol 16 59-63, 1932. See Hirschowitz BI. Pepsinogen Its origin, secretion and excretion. Physiol Rev 37 475-511, 1957, for a list of methods. 

Hirschowitz BI. Urinary excretion of pepsinogen in gastroduodenal ulceration. 

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