PEP inhibitors

Among numerous low molecular weight inhibitors of PEP described, two pro-linal derivatives have been reported as PEP inhibitors ONO 1603 63 [72] and Z Pro-prolinal 64 [73], in which the formyl group is able to react with the active site of the enzyme, Eq. (24) [74]. 

PEP(1470nM) [productsgive taste to tea] PEP inhibitors are potential anti-amnesics since PEP involved in metabolism of memory-linked vasopression, substance P thyrotropin releasing hormone (TRH)... 

The prolyl endopeptidase (PEP) inhibitor eurystatin A has been synthesized by two distinct strategies that incorporated the P-3CR. A particularly efficient approach used protected ornithine 60 as the carboxylic... 

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