Pentetrazole

Whereas the genetic and kindling models have been widely used to investigate possible neurotransmitter defects that cause different types of epilepsy, rodent models in which seizures are induced by electroshock, or by convulsant drugs such as pentylenetetrazol (also called pentetrazol, leptazol), picrotoxin or bicuculline, are mainly used in screening procedures to identify potential anticonvulsants. 

Pentetrazol. 6,7,8,9-Tetrahydro-577-tetrazolo[l,5-,2]azepine 16, analgesic, circulatory stimulant. 

Common Name Corazol Leptazol Pentamethylentetrazol Pentetrazol Pentylenetetrazol... 

Miscellaneous Central Nervous System Stimulants Amiphena-zole, bemegnde, doxapram, ethamivan, mkethamide, pentetrazol, pierotoxin, stryehnine, and related eompounds... 

Pentetrazol (pentylenetetrazol) Penthienate methobromide (also called penthienate bromide) Pethidine (meperidine)... 

Seizures associated with imipenem + cilastatin have repeatedly been reported (5-7). As with other beta-lac-tam antibiotics, it is difficult to assess clearly the cause of a seizure in patients with a cluster of other predisposing factors for neurotoxicity (8) and hence to reach clear estimates of frequency. In a review of 1754 patients there was a similar incidence of seizures with imipenem -I- cilastatin as with other antibiotic regimens usually containing another beta-lactam (9). In rabbits imipenem -I- cilastatin and another carbapenems were more neurotoxic than benzylpenicillin (10). In mice, ataxia and seizures were seen, with much lower blood concentrations of imipenem than cefotaxime or benzylpenicillin (1900 pg/ml versus 3400 qg/ml and 5800 qg/ml) (11). In mice imipenem also lowered the convulsive threshold of pentetrazol (pentylenetetrazole) more than cefazolin or two other carbapenems (12). Cilastatin alone was not proconvulsant, but it increased the effects of co-adminis-tered imipenem. 

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