Pentazocine Aspirin

A dissolution procedure for pentazocine hydrochloride and aspirin tablets is set forth in Addendum a, Second Supplement to the USP XX. The procedure is carried out with apparatus number one at 80 rpm using water as the dissolution medium. 

Pentazocine is identified in the combination product pentazocine hydrochloride and aspirin tablets by a method given in Addendum a, 2nd Supplement of USP XX. A silica gel TLC system is used with the solvent system ethyl acetate methanol formic acid (90 5 5). Detection is by UV, iodine vapor and iodoplatinate spray (4). 

Oxycodone is a codeine congener that appears to be 10 to 12 times more potent than codeine. When taken orally, oxycodone is as potent as parenteral morphine, and, like codeine, oxycodone retains most of its parenteral potency when given orally. When compared with codeine, morphine, or pentazocine, oxycodone may also have a lower incidence of side effects, but it produces euphoria and thus has potential for abuse. Oxycodone is commercially available in combination with acetaminophen, aspirin, or ibuprofen (see Table 7-7)... 

Warfarin + aspirin Significant increase in anticoagulant effect with possible severe Gl blood loss Displacement from protein Combination should be avoided if possible. Use alternative analgesic such as paracetamol or pentazocine... 

Pentazocine as the lactate is available in injection form containing the base equivalent of 30 mg/mL. buffered to pH 4 to 5. It should nut be mi.xcd with barbiturate.s. Tablets of 50 mg (as the hydrochloride in combination with naloronc to prevent abuse) are available for oral adminLstration. It is also available in combination with aspirin (Talwin Compound) and with acetaminophen (Talacen). 

In a controlled post-surgical analgesic study oral pentazocine was compared to codeine, aspirin, and a placebo. Pentazocine 50 mg was as effective as codeine 60 mg and more effective than 600 mg of aspirin. Pentazocine 35 mg was more effective than the placebo but less effective than the aspirin. It was found that the analgesic potency of the placebo was quite high and, as a second dose, was functionally dependent on the previous medication. 

Wilson, T.D. Recent advances in HPLC analysis of analgesics. J.Liq.Chromatogr., 1986, 9, 2309-2410 [also antipyrine, aspirin, buprenorphine, butorphanol, codeine, cyclazocine, diamorphine, dihydrocodeine, etorphine, fentanyl, heroin, hydrocodone, hydromorphone, ibuprofen, LAAM, levorphanol, meperidine, methadone, morphine, nalbuphine, naproxen, oxycodone, ox nnorphone, pentazocine, phenacetin, phenazocine, phenylbutazone, propoxyphene, salicylamide, salicylic acid, zomepirac]... 

Noninterfering acetaminophen, aspirin, amitriptyline, huprenorphine, caffeine, carba-mazepine, chlorpromazine, desipramine, dextromethorphan, doxepin, ephedrine, fenfluramine, imipramine, lidocaine, loxapine, meperidine, methadone, methaqualone, naloxone, naltrexone, nicotine, orphenadrine, oxycodone, papaverine, pentazocine, phendimetra-zine, phenmetrazine, phentermine, phenylpropanolamine, phenytoin, primidone, procaine, promethazine, propoxyphene, propyphenazone, theobromine, theophylline, trazodone, triflupromazine, trimethoprim, trimipramine... 

Simultaneous alimemazine, amitriptyline, amphetamine, bupivacaine, buprenorphine, clomipramine, cocaine, codeine, ethylmorphine, glafenine, meperidine, methampheta-mine, methotrimeprazine, morphine, norcodeine, nortriptyline, pentazocine Noninterfering acetaminophen, aspirin, barbiturates, benzoylecgonine, caffeine, diazepam, flunitrazepam, lidocaine, lorazepam, nalorphine, naloxone, nitrazepam, nordiaze-pam, norflunitrazepam, normorphine, oxazepam, prazepam, triazolam, zolpidem Interfering cyamemazine, desipramine, imipramine... 

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