Pentagastrin-stimulated gastric

On a weight basis 20 times more potent than cimetidine and 7.5 times more potent than ranitidine in inhibiting basal and pentagastrin stimulated gastric acid secretion. It is a competitive-noncompetitive inhibitor of receptors. It has a long-... 

Andrews F, Jenkins C, Frazier D et al 1992 The effect of oral omeprazole on basal and pentagastrin-stimulated gastric secretion In young female horses. Equine Veterinary Journal Supplement 13 80-83 Andrews F M, Sifferman R L, Bernard W et al 1999 Efficacy of omeprazole paste in the treatment and prevention of gastric ulcers in horses. Equine Veterinary Journal Supplement 29 81-86... 

Simon B, Muller P, Marinis E, et al. Effect of repeated oral administration of BY1023/SK F96022—a new substituted benzimidazole derivative-on pentagastrin-stimulated gastric add secretion and pharmacokinetics in man. Aliment Pharmacol Ther 1990 4 373-379. 

Jansen JB, Lundborg P, Baak LC, et al. Effect of single and repeated intravenous doses of omeprazole on pentagastrin stimulated gastric acid secretion and pharmacokinetics in man. Gut 1988 29(1) 75-80. 

Hirschowitz BI, Sachs G (1969) Atropine inhibition of insulin-, histamine- and pentagastrin-stimulated gastric electrolyte and pepsin secretion in the dog. Gastroenterology 56(4) 693-702... 

For testing the antisecretory potential gastric acid secretion is stimulated either by i.v. infusions of histamine (0.1 mg/kg/h), carbachol (10 ig/kg/h), or pentagastrin (8 rg/kg/h). When stimulated gastric acid secretion has reached a stable plateau (after 1.5 hours) the candidate compound is administered orally or by i.v. injection and secreted fluid is collected at 15 or 30 min intervals and analyzed for free HC1. 

There is a sex-related difference in human gastric acid secretion. Healthy women secrete significantly less basal and pentagastrin-stimulated acid then men with a median 24h integrated acidity of 485 mmol h vs. 842mmol h / In a sample of 365 healthy subjects, the average basal pH was 2.16 0.09 for men and 2.79 0.18 in women. ... 

Buttner D, Cartsburg R. Akute pankreatitis nach Magensekretionsanalyse unter Pentagastrinstimulation. [Acute pancreatitis following gastric secretion analysis by pentagastrin stimulation.) MMW Munch Med Wochenschr 1978 120(50) 1679-80. 

Omeprazole administered i.v. (0.5 mg/kg once daily) had a pronounced effect on basal acid output and gastric pH within 2h of administration, and basal and pentagastrin-stimulated acid output were significantly inhibited 24 h after the fourth consecutive dose (Jenkins et al 1992b). 

Omeprazole admmistered i.m. (0.25 and 1.0 mg/ kg) similarly inhibited basal and pentagastrin-stimulated acid output and increased gastric pH, with a greater response to the higher dose rate (Sandin et al 1999). Peak plasma levels of omeprazole were measured 20 min after administration and thereafter plasma levels rapidly declined (half-life of 45 to 60 min). Inhibition of acid secretion persisted for many hours after the plasma levels had declined to barely detectable. TTie bioavailability of the i.m. administered omeprazole was 75%. 

Merritt A M, Burrow J A, Horbal M J et al 1996 Effect of omeprazole on sodium and potassium output in pentagastrin-stimulated equine gastric contents. American Journal of Veterinary Research 57 1640-1644 Merritt A M, Burrow J A, Hartless C S 1998 Effect of xylazine, detomidine and a combination of xylazine and butorphanol on equine duodenal motility. American Journal of Veterinary Research 59 619-623... 

Inhibition of gastric acid secretion 50 mg, no effect on basal acid secretion 2.5,10, 50 mg p.o. inhibited pentagastrin-stimulated acid secretion (0.05-2 /Jtg kg- h" ) (227). 

N. and Ribet, A. (1990) Gastric lipase in alcoholic pancreatitis. Comparison of secretive profiles following pentagastrin stimulation in normal adults and patients with pancreatic insufficiency. Gastroenterology 99, 175-180. 

SzAFRAN, Z., SzAFRAN, H., POPIELA, T. and Trompeter, G. (1978) Coupled secretion of gastric lipase and pepsin in man following pentagastrin stimulation. Digestion 18, 310-318. 

Lind, X, Cedeberg, C., Ekenved, G., Haglund, U., Olbe, L. Effect of omeprazole - a gastric proton pump inhibitor - on pentagastrin stimulated acid secretion in man. Gut 1983, 24, 270-276. 

The pentapeptide, pentagastrin, has replaced natural gastrin (a heptadeca-peptide) as a diagnostic agent that stimulates gastric secretion. This pentapeptide is butyloxycarbonyl-)8-Ala-Trp-Met-Asp-Phe-NH2. It can be administered as a snuff. 

Chandler AM, Johnson LR. Pentagastrin-stimulated incorporation of " C-orotic acid into RNA of gastric and duodenal mucosa. Proc Soc Exp Biol Med 141 110-113, 1972. 

Corticosteroids induce hypergastrin-aemia, but pentagastrin-stimulated acid and pepsin output are not affected (116). Corticosteroids, in acute studies, did not influence ion fluxes across human gastric mucosa (62). 

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