2.2.3.3.3- pentafluoro-l - propanol

A rapid, automated procedure for single-step and simultaneous extraction of cocaine and 11 related compounds was developed by Lewis et al. [95]. Fluid and tissue specimens were extracted using an automated SPE system (Zymark Rapid-Trace) with a Bond Elute-Certify I cartridge. Samples were derivatized with pentafluoro-propionic anhydride/2,2,3,3,3-pentafluoro-l-propanol prior to GC-MS analysis. The method allowed differentiation between smoking crack and intranasal/intravenous cocaine use and was able to elucidate whether ethanol and cocaine were used simultaneously. Another way to determine cocaine in biological matrices is to measure its metabolites and/or degradation products. MEG is produced when... 

Pentafluoropropane 2,2,3,3,3-Pentafluoro-l-propanol 2,3.4.5.6-Pentatluorotoluene 1,1,2,4,4-Peritafluoro-3-(trifluoromethyl)-1,3-butadiene... 

Trifluoromethylpyridazines of type S could be prepared starting from 2-amino-1,1,l-trifluoro-3-phenylsulfonyl-2-propanol (93H(35)909). Compounds of type 6 are conveniently accessible by cyclisation of l,l,l,2,2-pentafluoro-3,4-alkanedione 4-diaIkylhydrazones [93TL(34)5135J. 3-(Trifluoromethyl)-4-pyri-dazinecarboxylates of type 7 have been obtained upon reaction of 2-(alkylamino)-3-(trifluoroacetyl)butenedioates with substituted hydrazines (93JHC(30)1501. ... 

Alkylated barbituric acids, 6-chloro-a-methylcarbazole-2-aceticacid, 1-phenylethanol, 1-phenyl-1-propanol, dimethyl, 3,4,5,6-pentafluoro-benzyl alcohol, l-(2-naphthyl)-ethanol, 1 -(p-biphenyl)-ethanol Chirasil-Dex coated column, 0.15 pm... 

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