2.2.3.3.3- pentafluoro-l -

A rapid, automated procedure for single-step and simultaneous extraction of cocaine and 11 related compounds was developed by Lewis et al. [95]. Fluid and tissue specimens were extracted using an automated SPE system (Zymark Rapid-Trace) with a Bond Elute-Certify I cartridge. Samples were derivatized with pentafluoro-propionic anhydride/2,2,3,3,3-pentafluoro-l-propanol prior to GC-MS analysis. The method allowed differentiation between smoking crack and intranasal/intravenous cocaine use and was able to elucidate whether ethanol and cocaine were used simultaneously. Another way to determine cocaine in biological matrices is to measure its metabolites and/or degradation products. MEG is produced when... 

Methyl-2-pentafluoroethyl-J -5-oxazolone (as a mixture with perfluoropropionic acid from its prepn. with perfluoropropionic anhydride and DL-alanine) added dropwise with stirring and ice-cooling to a mixture of HBr-glacial acetic acid and ethyl mercaptan, well shaken, and allowed to stand 1 hr. in the ice-bath 2,2,3,3,3-pentafluoro-l-ethylthiopropylamine hydrobromide. Y 79%. F. e. s. F. Weygand, W. Steglidi, and W. Oettmeier, B. 103, 818 (1970). 

Pentafluoropropane 2,2,3,3,3-Pentafluoro-l-propanol 2,3.4.5.6-Pentatluorotoluene 1,1,2,4,4-Peritafluoro-3-(trifluoromethyl)-1,3-butadiene... 

Dihydro-5-methyl-2-(4-methylphenyl)-4-(2,2,3,3,3-pentafluoro-l-oxopropyl)-3//-pyrazol-3-one, D-00433... 

---