Penicillium wortmannii

The first example of an irreversible inhibitor is the natural product Wortmannin, which was isolated from Penicillium wortmannii [30], Wortmannin effectively inhibits PI3K at low nanomolar concentration and was shown to be specific across a large panel of kinases [31]. Covalent attachment to PI3K occurs after attack by Lys-883, which is essential for phosphate transfer (see Section 7.2), at the furan ring of Wortmannin [32], Attack at this ring specifically occurs within the catalytic site of the PI3K kinase and is unaffected by nucleophiles in aqueous solution. 

Monascus ruber Monascus ruber Penicillium rubrum Talaromyces udagawae Penicillium rubrum Penicillium wortmannii Penicillium vermiculatum Penicillium funiculosum Penicillium vermiculatum Talaromyces tardifaciens Penicillium wortmannii Aspergillus ustus... 

Penicillium wortmannii produces a metabolite, 11-desacetoxywortmannin (99), in which ring a is cleaved. It is formed from lanosterol, and the incorporation of... 

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