Penicillium thomii

Oxo-aldehyde konnen nur in Einzelfallen selektiv an der Formyl-Gruppe reduziert werden. Beispiel hierfiir ist die Reduktion von 14/3-Hydroxy-3,19-dioxo-cardadien-(4,2022)-olid mit Penicillium thomii zu 14(i,19-Dihydroxy-3-oxo-cardadien-(4,2022)-olid (55% d.Th.)5 die an sich reaktive 3-Oxo-Gruppe (s.S. 748) ist durch Konjugation mit der C4=Cs-DoppeIbindung desaktiviert (s.a. S.742) ... 

Honda and co-workers applied the above procedure to the formal total synthesis of enantiopure (-)-TAN1251A (45b), a muscarinic receptor antagonist, isolated from a culture of Penicillium thomii RA-89 [121]. The best yield of the spiroannulation reaction of the phenol 156 using PIDA was achieved by the reaction in (CF3)2CHOH similar to the Sorensen s procedure [119]. Incidentally, none of the desired product was obtained by the typical stepwise procedure using chlorination with NCS followed by Ag20 oxidation (Scheme 29). 

Paecilomyces victoria Parmelia birulae Peltophorum interme Penicillium brevicompactum Penicillium canescens Penicillium citreo-viride Penicillium citrinum Penicillium cyclopium Penicillium duclauxi Penicillium herquei Penicillium stipitatum Penicillium thomii Penicillium viridicatum Peniophora sanguinea Periconia macrospinosa Pestalotia ramula Pseudomonas yoshitomiensis Pyricularia oryzae... 

Ceratocystis fimbriata Kigelia pinnata Penicillium thomii Sporormia bipartis Sporormia affinis Biosynthesis Synthesis... 

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