Penicillins, serum binding antibiotic

Nevertheless, it was necessary to give three equations with different constants for penicillins with an a-amino or a-ether group in the side-chain, or with an ortho aromatic ether group (methicillin analogues). It was suggested that the mechanism involves hydrophobic binding and /3-lactam antibiotics are able to bind to serum when ionic sites for this are not available, e.g. the case of penicillin amides, cephalosporin lactones (Table 8.9) and certain 2-substituted cephalosporins (Table 8.7), when the increased lipophilicity leads to increased serum binding. 

Terasaki, T. Nouda, H. Tsuji, A. Relationship between lipophilicity and binding affinity with human serum albumin for penicillin and cephem antibiotics. J.Pharmacobiodyn., 1992, IS, 99—106... 

The P-lactam antibiotics continued to be the cynosure of synthesis. Some structure-activity relationships of peni-cillins O and cephalosporins 2 v/ere discussed. Timely reports aimed primarily toward the evaluation of the newer highly serum-bound penicillins dealt with the controversial relationship of drug-serum protein binding to clinical antimicrobial effectiveness. 3,14... 

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