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Pegfilgrastim

Molineux G (2004) The design and development of pegfilgrastim (PEG-rmetHuG-CSF, Neulasta). Curr Pharm Des 10 1235-1244... [Pg.581]

Pegfilgrastim Neulasta Neutrophil 6 mg SQ one time Bone pain (approximately 25%) Once per cycle dosing Administer 1-3 days after chemotherapy... [Pg.1471]

Is the ANC on the way down (before nadir) or on the way up (after nadir) Was the patient receiving prophylactic antibiotics, prophylactic filgrastim, or sar-gramostim or received prophylactic pegfilgrastim ... [Pg.1474]

Renwick W, Pettengell R, Green M (2009) Use of filgrastim and pegfilgrastim to support delivery of chemotherapy twenty years of clinical experience. BioDrugs 23 175-186... [Pg.136]

Neulasta, Pegfilgrastim, G-CSF-PEG Amgen, Inc. Infection, as manifested by febrile neutropenia, in patients with non-myeloid malignancies receiving myelo-suppressive anti-cancer drugs Jan. 2002... [Pg.150]

Filgrastim [G-CSF] (Neupogen) Oprelvekin (Neumega) Pegfilgrastim (Neulasta)... [Pg.50]

Pegfilgrastim (Neulasla) [Colony Stimulating Factor] Uses i... [Pg.249]

Neulasta (PEGfilgrastim, rPEGyl-ated filgrastim — see Neupogen). Also marketed in EU as Neupopeg... [Pg.502]

Dosage form Neulasta is supplied in 0.6 ml prefilled syringes. Each syringe contains pegfilgrastim 6 mg (based on protein weight) and excipients in a sterile solution. [Pg.158]

Pharmacokinetics The pharmacokinetics of pegfilgrastim were studied in 379 patients with cancer. The pegylated version of filgrastim demonstrated nonlinear pharmacokinetics, and clearance decreased with increases in dose. Neutrophil receptor binding is an important component of pegfilgrastim clearance, and serum clearance is directly related to the number of neu-... [Pg.158]

Like G-CSF and pegfilgrastim, GM-CSF also reduces the duration of neutropenia after cytotoxic chemotherapy. It has been more difficult to show that GM-CSF reduces the incidence of febrile neutropenia, probably because GM-CSF itself can... [Pg.746]

Pegfilgrastim Long-acting form of filgrastim that is covalently linked to a type of polyethylene glycol ... [Pg.750]

Pegfilgrastim) [covalent conjugate of recombinant methionyl human G-CSF and 20 kD PEG]... [Pg.322]

Like G-CSF and pegfilgrastim, GM-CSF also reduces the duration of neutropenia after cytotoxic chemotherapy. It has been more difficult to show that GM-CSF reduces the incidence of febrile neutropenia, probably because GM-CSF itself can induce fever. In the treatment of chemotherapy-induced neutropenia, G-CSF, 5 g/kg/d, or GM-CSF, 250 g/m2/d, is usually started within 24-72 hours after completing chemotherapy and is continued until the absolute neutrophil count is >... [Pg.756]

Pegfilgrastim/Neulasta Hematopoietic stimulant Amgen SC Nonlinear PK 15-80 h... [Pg.21]

See other pages where Pegfilgrastim is mentioned: [Pg.579]    [Pg.1297]    [Pg.213]    [Pg.370]    [Pg.944]    [Pg.134]    [Pg.134]    [Pg.157]    [Pg.157]    [Pg.158]    [Pg.158]    [Pg.359]    [Pg.453]    [Pg.453]    [Pg.478]    [Pg.556]    [Pg.744]    [Pg.746]    [Pg.746]    [Pg.747]    [Pg.49]    [Pg.754]    [Pg.755]    [Pg.756]    [Pg.759]    [Pg.1308]   
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