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Pegaspargase

There is an increased risk for bone marrow suppression when levamisole or hydroxyurea are administered witii other antineoplastic dni. Use of levamisole witii phenytoin increases die risk of phenytoin toxicity. Pegaspargase may alter drug response of the anticoagulants. When procarbazine is administered with other central nervous system (CNS) depressants, such as alcohol, antidepressants, antihistamines, opiates, or the sedatives, an additive CNS effect may be seen. Procarbazine may potentiate hypoglycemia when administered witii insulin or oral antidiabetic dru . ... [Pg.594]

Pegaspargase 2,500 units/m2 per dose IM for 1 dose or asparaginase 6,000 units/m2 per dose IM Mon, Weds, and Fri for 6 doses Intrathecal methotrexate weekly for 2-4 doses Consolidation (1 month)... [Pg.1407]

Graham ML. Pegaspargase a review of clinical studies. Adv Drug Deliv Rev 2003 55(10) 1293-302. [Pg.463]

Dosage form Oncaspar is a preservative-free, sterile solution in buffered sahne in 5 ml single-dose vials. Each ml contains pegaspargase 750 lU. [Pg.261]

Pharmacokinetics The elimination half-life of pegaspargase has been estimated to be 5.7 days, compared with a half-life of a few minutes up to 5 hours for L-asparaginase, and its volume of distribution has been estimated to be 2.1 liters/m. ... [Pg.262]

Disposition Metabolism of pegaspargase appears to be similar to that of L-asparaginase, which is inactivated by serum proteases, as well as immune and reticu-lendothelial systems. [Pg.262]

Pegaspargase, L-asparagjnase conjugated to PEG (5000), E. coli-derived enzyme... [Pg.477]

Pegaspargase is a modined version of asparaginase in which the en/.yme is covalently conjugated with strands of polymeric monomethoxypropylene glycol (PEG), which liave molecular weights of about 5,000. It is used in combi-tution chemotherapy of patients with ALL who arc sensitive 111 natural i.-usparaginasc. [Pg.429]

Fareston - toremifene Oncaspar- pegaspargase Xeloda - capecitabine... [Pg.395]

Oncaspar pegaspargase Flexon, Myolin, Norflex, Norgesic, Opheryl, Orfenace,... [Pg.669]

See other pages where Pegaspargase is mentioned: [Pg.593]    [Pg.1292]    [Pg.1407]    [Pg.1408]    [Pg.595]    [Pg.612]    [Pg.596]    [Pg.614]    [Pg.457]    [Pg.261]    [Pg.261]    [Pg.359]    [Pg.452]    [Pg.518]    [Pg.518]    [Pg.556]    [Pg.324]    [Pg.371]    [Pg.21]    [Pg.27]    [Pg.40]    [Pg.333]    [Pg.577]    [Pg.951]    [Pg.23]    [Pg.431]    [Pg.400]    [Pg.207]    [Pg.215]    [Pg.442]    [Pg.671]    [Pg.70]    [Pg.331]    [Pg.2310]    [Pg.2310]   
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See also in sourсe #XX -- [ Pg.349 ]



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