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Peg interferon alfa-2b

Peg Interferon Alfa 2b (PEG-Intron) [Antiviral/ Immunomodulator] WARNING Can cause or aggravate fatal or life-threatening neuropsychiatric, autoimmune, ischemic, and infectious disord s. Monitor pts closely Uses Rx Hep C Action Immune modulation Dose 1 mcg/kg/wk SQ 1.5 mcg/kg/wk combined w/ ribavirin Caution [C, X if used w/ ribavirin /-] w/ Hx psychiatric Contra Autoimmune H, decompensated Uvct Dz, hemoglobinopathy Disp Vials 50, 80, 120, 150 mcg/0.5 mL Redipen 50, 80,120,150 mcg/5 mL reconstitute w/ 0.7 mL w/ sterile water SE D ession, insomnia, suicidal behavior, GI upset, neutropenia, thrombocytopenia, alopecia, pruritus Interactions t Myelosuppression W/ antineoplastics t effects OF doxorubicin, theophylline t neurotox W7 vinblastine EMS See Peg Interf on Alfa-2a may cause flu-like Sxs... [Pg.250]

Interferons interferon alpha-nl, interferon alpha-n3, interferon alpha-2a, peg interferon alfa-2b, interferon alfacon-1, Interferon alpha-2b, interferon beta-lb, interferon gamma-lb,... [Pg.36]

Jensen SL+, J Drugs Dermatol 2(5), 554 (with PEG-interferon alfa-2B)... [Pg.502]

Mukherjee S +, J Gastroenterol Hepatol 20(2), 198 (with PEG-interferon alfa-2b)... [Pg.503]

Pharmacokinetics Pegylation of interferon alfa-2b produces a product whose clearance is substantially lower that than of nonpegylated interferon alfa-2b. The mean absorption half-life of peginterferon alfa-2b following a single subcutaneous injection of PEG-Intron is 4.6 hours. Time to peak concentration is variable and may... [Pg.205]

E. Therapeutic response A randomized trial compared treatment with PEG-Intron, once weekly, to treatment with Intron A (interferon alfa-2b), three times weekly, in 1219 previously untreated adults with chronic hepatitis from HCV infection. Patients were treated for 48 weeks. Response to treatment was defined as undetectable HCV RNA (less than 100 copies per ml) and normalization of the liver enzyme alanine aminotransferase (ALT) at 24 weeks post-treatment. Response rates to the l.Opg/kg PEG-Intron doses and to Intron A were 24% and 12%. Patients receiving PEG-Intron with viral genotype 1 had a response rate of 14%, while patients with other viral genotypes had a 45% response rate. [Pg.206]

Peginterferon alfa-2b (pegylated interferon alfa-2b, PEG-Intron)... [Pg.1089]

Interferons and cytokines Peginterferon aha-2b, PEG-modified human recombinant inteferon alfa-2b (Intron A, produced in E. coh) PEG-Intron Lyophilized 74,118,177, or 222 ig in 2 ml vial sc... [Pg.462]

Covalent conjugate of recombinant alfa-2b interferon with monomethoxyl polyethylene glycol (PEG) (type 1 interferon)... [Pg.439]

See other pages where Peg interferon alfa-2b is mentioned: [Pg.37]    [Pg.250]    [Pg.36]    [Pg.50]    [Pg.250]    [Pg.503]    [Pg.503]    [Pg.503]    [Pg.503]    [Pg.36]    [Pg.50]    [Pg.250]    [Pg.37]    [Pg.250]    [Pg.36]    [Pg.50]    [Pg.250]    [Pg.503]    [Pg.503]    [Pg.503]    [Pg.503]    [Pg.36]    [Pg.50]    [Pg.250]    [Pg.238]    [Pg.343]    [Pg.356]    [Pg.227]    [Pg.205]    [Pg.1149]    [Pg.953]    [Pg.953]    [Pg.451]    [Pg.76]    [Pg.359]    [Pg.489]    [Pg.331]    [Pg.331]    [Pg.266]   
See also in sourсe #XX -- [ Pg.250 ]

See also in sourсe #XX -- [ Pg.250 ]

See also in sourсe #XX -- [ Pg.250 ]



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