PDZ domain proteins

Kuchinke U, Grawe F, Knust E 1998 Control of spindle orientation in Drosophila by the Par-3-related PDZ-domain protein Bazooka. Curr Biol 8 1357—1365... 

Tsunoda, S., Sierralta, J., Sun, Y, Bodner, R., Suzuki, E., Becker, A., Socohch, M. and Zuker, C.S. A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade (1997) Nature 388, 243-249... 

NMDA receptors are clustered at postsynaptic sites where cytoplasmic adapter proteins anchor them to the cytoskeleton. Some adapter proteins contain a PDZ domain while others lack this. The PDZ domain is a protein-protein interaction motif of approximately 90 amino acids, which in most cases, binds their target proteins at the C-terminus ends. For example a PDZ domain protein, PSD-95, interacts with the C-terminus of the NR2 subunit. Its interaction with tubulin-based cytoskele-tal protein is mediated by a novel postsynaptic protein called CRIPT (Niethammer et al., 1998). Thus NR1 and NR2 subunits and their related proteins are crucial for efficient gating of NMDA receptor channels. 

Ganguly S., Mackay T. F. C., Anholt R. R. H. and Keck W. M. (2001) Scribble a PDZ domain protein that contributes to sexually dimorphic olfactory avoidance behavior in Drosophila. Annu. Drosophila Res. Conference 42, (Abstract). 

Fig. 2. Novel receptor-interacting partners of selected 5-HT receptors, their interaction domains on the receptors, and consequences of the interactions. Abbreviations CaM, Ca2+/calmodulin PDZ, a protein interaction domain termed postsynaptic density 95/discs large/ZO-1 PSD-95, a key protein component of the excitatory postsynaptic density MUPP1, multi-PDZ-domain protein SNX27a, a member of the new sorting nexin family of proteins NHERF, NHE regulatory factor. MUPP1 prevents phosphorylation of serine-458 of the 5-HT2C receptor.

Becamel C, Figge A, Poliak S, et al. Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1. J Biol Chem 2001 276 12,974-12,982. 

Ullmer C, Schmuck K, Figge A, Lubbert H. (1998) Cloning and characterization of MUPP1, a novel PDZ domain protein. FEBS Lett 1998 424 63-68. 

Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ. CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members NMD A receptor subunits, neurexins, and neuroligins. Mol Cell Neurosci 1998 11 161-172. 

Kurschner C, Yuzaki M (1999) Neuronal interleukin-16 (NIL-16) a dual function PDZ domain protein. J Neurosci 19 7770-7780... 

S. Tsunoda, et al. A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade. Nature, 388, 243—249, 1997. 

Key Words Adipocyte P-adrenergic receptors apoptosis cardiovascular caveolae knockout metabolite mitogen-activated protein kinase myocyte PDZ domain protein kinase A anchoring protein. 

Kornau HC, Seeburg PH, Kennedy MB (1997) Interaction of ion channels and receptors with PDZ domain proteins. Curr Opin Neurobiol 7 368-373. 

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