Pazufloxacin Theophylline

Niki Y, Watanabe S, Yoshida K, Miyashita N, Nakajima M, Matsushima T. Effect of pazufloxacin mesi-late on the serum concentration of theophylline. J Infect Chemother 2002 8(l) 33-6. 

Co-administration of pazufloxacin and theophylline has been studied in rats (2). Pazufloxacin reduced the clearance of theophylline by about 25%. In seven healthy volunteers taking modified-release theophylline, intravenous pazufloxacin mesilate increased serum theophylline concentrations analysis of the urinary excretion of theophylline and its metabolites suggested that CYP1A2 had been inhibited (2). Theophylline concentrations need to be monitored if pazufloxacin is co-administered. 

Theophylline serum levels can be markedly increased in most patients by enoxacin. Pipemidic acid and clinafloxacin probably interact similarly. Theophylline levels can also be markedly increased in some patients by ciprofloxacin, and possibly pe-floxacin. Norfloxacin, ofloxacin, pazufloxacin, or prulifloxacin normally cause a much smaller rise in theophylline levels. However, serious toxicity has been seen in few patients given norfloxacin. Fleroxacin, flumequine, gatifloxacin, gemifloxacin, levofloxacin, lomefloxacin, moxifloxacin, nalidixic acid, rufloxacin, spar-floxacin and trovafloxacin appear not to interact. 

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