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Paulson, James

A simplified one-pot two-step enzymatic approach was used by James Paulson s group to produce sialoside derivatives (23). Instead of recycling the CMP-sialic acid, the sialyltransferase donors with modifications at C-5 or C-9 position of NeuSAc were enzymatically synthesized from ManNAc or its C-2 or C-6 modified derivatives, pyruvate, and CTP using a sialic acid aldolase and a CMP-Neu5Ac synthetase/sialyltransferase fusion protein. After removing the protein by membrane filtration, the filtrate containing produced CMP-sialic acid... [Pg.98]

Paulson DR, Addison AW, Dolphin D, James BR (1979) J Biol Chem 254 7002... [Pg.122]

Acknowledgments The authors thank Professor James C. Paulson and Dr. Weihsu C. Chen, The Sciipps Research Institute, for cell-based assays for the glycoclusters. The authors also thank Hiroaki Asai, Dr. Michio Sasaoka, Kazuhiro Fukae, and Azusa Hashrmoto, Otsuka Chemical Co., Ltd. for supplying Al-glycans. This work was supported in part by Grants-in-Aid for Scientific Research No. 19681024 and 19651095 from the Japan Society for the Promotion of Science,... [Pg.225]

See other pages where Paulson, James is mentioned: [Pg.396]    [Pg.396]    [Pg.250]    [Pg.354]    [Pg.25]    [Pg.65]    [Pg.498]    [Pg.517]    [Pg.518]    [Pg.1883]    [Pg.1882]    [Pg.517]    [Pg.518]    [Pg.3971]    [Pg.3972]    [Pg.199]    [Pg.3]    [Pg.68]    [Pg.69]   
See also in sourсe #XX -- [ Pg.498 ]



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