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Pattern-recognition receptors PAMPs

Other pathogen-associated molecules called PAMPs, for pathogen-associated molecular patterns, have been recently described (Jeannin et ah, 2002). These highly conserved structures are recognized by innate cells. Recent evidence shows that this recognition can mainly be attributed to non-clonally distributed receptors called pattern-recognition receptors, or PRRs,... [Pg.260]

The first tier is primarily controlled by pattern recognition receptors (PRRs) that are activated by recognition of evolutionarily conserved pathogens or microbial-associated molecular patterns (PAMPs or MAMPs, here P/MAMP). Activation of PRRs leads to intracellular signalling, transcriptional reprogramming and biosynthesis of a complex output response that limits colonization. The system is known as PAMP-triggered immunity (PTI). " The second tier is effector-triggered immunity (ETI), which consists of a series... [Pg.200]

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