Patient compliance dosing record

The crucial step is to use the objective record of the patient (prior dosing) as a management tool to allow the patient to see what errors were made and to discuss options for how to avoid such errors in the future. This step is wholly new, for prior efforts to improve compliance have relied on patients self-reported compliance, which is subject to errors due to imperfect memory, mixed feelings about the treatment program and a desire to please the physician. 

Infection of bone, known as osteomyelitis, remains one of the most serious clinical complications associated with open reduction and internal fracture fixation. Gonventional intravenous therapy with systemic antibiotics is the major modality of treatment employed by clinicians, but such therapy has inherent drawbacks. Long-term intravenous therapy often requires the use of indwelling intravenous lines which have the potential for serious morbidity including line infections and deep venous thromboses. In addition, dosing of the antibiotics may be as often as several times per day, which can lead to a decrease in patient compliance as well as increased risk of infection. Additionally, many systemic antibiotics have relatively narrow therapeutic windows, and their potential for toxicity requires close clinical monitoring. But even when drug toxicity and line-related complications are avoided, treatment of such infections has a less-than-impressive success record. - ... 

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