Pathophysiology of Parkinson Disease

The relationship between these two neurotransmitters suggests that the role of striatal dopamine may be to modulate acetylcholine release that is, the lack of 

FIGURE 10-1 Schematic representation of the neurotransmitter imbalance in Parkinson disease. Normally, a balance exists between dopamine and acetylcholine in the basal ganglia. In Parkinson disease, decreased dopaminergic influence results in increased acetylcholine influence. 

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