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Pathophysiology neuronal mechanisms

Leong DK and Butterworth RF (1996) Neuronal cell death in Wernicke s encephalopathy pathophysiologic mechanisms and implications for PET imaging. Metabolic Brain Diseases 11,71-9. [Pg.436]

Ischemic injuries have been extensively studied in the brain in the context of stroke however, much remains to be learnt about the pathophysiological mechanisms. Excitotoxicity is an important contributing mechanism, especially in the areas where the blood supply is not critically reduced. In addition, ischemia affects cell bodies and the axons differently (Petty and Wettstein, 1999). These differences are important in understanding the pathophysiology of glaucoma, where the key events may be occurring in the ganglion cell axons rather than in the cell bodies. Ischemia could injure the neurons by several different mechanisms or their combinations. [Pg.52]

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