Passerini multicomponent

Passerini multicomponent reaction Condensation of isocyanides with carboxylic acids and carbonyl compounds to afford a-acyloxycarboxamides. 330... 

Banfi, L., Guanti, G., Riva, R. Passerini multicomponent reaction of protected a-amino aldehydes as a tool for combinatorial synthesis of enzyme inhibitors. Chem. Common. 2000, 985-986. 

In the second communication, Passerini also determined that the addition of hydrogen peroxide was unnecessary and, to an extent, deleterious as it mediated the decomposition of /7-isonitrileazobenzene. The formation of a-acyloxyamides from isonitriles, carboxylic acids and ketones or aldehydes subsequently became known as the Passerini reaction or the Passerini multicomponent reaction. The process is sometimes denoted as P-3CR according to Ugi s classification of multicomponent reactions (MCR). ... 

A. R. Kazemizadeh, A. Ramazani, J. Braz. Chem. Soc. 2009,20, 309-312. Passerini multicomponent reaction of indane-1,2, 3-trione an efficient route for the one pot synthesis of stericaUy congested 2,2-disuhstituted indane-l,3-dione derivatives. 

The renewed popularity of the Passerini multicomponent reaction is due to its apphcation in the preparation of polymers from renewable materials and pep-tidomimetics [14—17]. 

Sehlinger A, Kreye O, Meier MAR (2013) Tunable polymtax obtained from Passerini multicomponent reaction derived acrylate monomers. Macnunolecules 46(15) 6031-6037... 

Deng X-X, Cui Y, Wang Y-Z, Du F-S, Li Z-C (2014) Graft copolymers with polyamide backbones via combination of Passerini multicomponent polymerization and controlled chain-growth polymerization. Aust J Chem 67(4) 555-561... 

Sienczyk and co-workers have presented a rapid method for the construction of libraries of biologically active phosphonic pseudopeptides products (627-629) via Ugi and Passerini multicomponent condensations. As the starting material diaryl isocyanoalkylphosphonate (626) has been... 

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