Partition various rabbit tissues

Tab. 4.26 Tissue-to-plasma partition coefficients (Kp) of basic drugs for various rabbit tissues , octanol-buffer partition coefficient, log Papp, and unbound fraction of drug in serum, fp (Adapted from Tab. 2 of ref. 91)...

In any type of ocular bum and later on rinsing therapy, we have found that the speed of the penetration was roughly correlated to the concentration of the corrosive and the type of corrosive. This question is still scientifically open but estimations of penetration of sodium hydroxide are from about 5-8 pm/s depth propagation into the tissues, derived from measurements of Rihawi et al. on rabbit corneas [43]. Theoretical work on penetration characteristics of different chemicals have been published by Pospisil and Holzhuetter [44]. They have proved that, in first order estimation, the chemical properties like molecular size and shape, partition coefficients, and the type of interaction with the intrinsic membrane parameters determine the penetration characteristics. In very good estimations, they have shown that, for a various set of test substances, the penetration is almost exactly predicted by their modelization. 

Detailed in vivo studies on the tissue distribution in rabbits of a set of 10 drugs have been reported together with their partition coefficients, Kp, in various tissues and partition coefficients log Papp in four solvent systems octanol, benzene, chloroform, and triolein [91]. The results are summarized in Table 4.26. The Kp values in the studied tissues, including bones, showed a large variation in ranking and a significant variation from tissue to tissue. It was found that the tissue-to-plasma partition coefficient of the non-ionized form of the dmgs, Kf,(w correlates best with log Poet. of the non-ionized form. 

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