Partition coefficient calculations, pyrethroid

Equation (23) for calculating f t was already available in the Excel spreadsheet (Table 6 Knaak et al. 2008) used to calculate the Poulin-Theil partition coefficients for the carbamates Knaak et al. (2008). To correct for protein binding, the nonadipose and adipose tissue equations [(14) and (16)] of Poulin-Theil were both multiplied by /up//ut- The revised Excel spreadsheets were used to calculate rat and human partition coefficients for the pyrethroids and their metabolites in Appendix D. 

The equation for the calculation of unbound tissue-plasma partition coefficients, pus, for neutral pyrethroids and their acidic metabolites is shown in (25). 

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