PARP-1 and Nuclear Death Signals

PARP-1 and Nuclear Death Signals Oxidative DNA Damage 

Tabk 1. Factors involved m nuclear morphologic chaises during cell death programs 

Ca -regulated serine proteases Histone-associated protease 

The synthesis and turnover of ADP-ribose polymers is dynamic. Poly(ADP-ribose) glycohydrolase (PARC) plays the major role in the degradadon of the polymer and it controls the level and complexity of polymerized PAR in vivo. In contrast to an array of different PARP proteins, only a single member of the PARC gene has been identified in mammals thus far. The cDNAs of PARC have been isolated and cloned from bovine, rat, human and mouse. PARC is translated into a catalytically active protein of approximately 111 kD, which can be cleaved by a protease to a 59 kD protein that is also catalytically active. The deduced amino acid sequence of the bovine PARC shares litde or no homology with other known 

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