Parkinsons Disease and Amyotrophic Lateral Sclerosis

Lee Mosley, Ashley Reynolds, David K. Stone, and Howard E. Gendelman 

Keywords Adaptive immunity Antibodies Dopaminergic neurons Glatiramer acetate Innate immunity Motor neurons Oxidative stress Superoxide dismutase a-Synuclein T cell T lymphocyte 

New modalides in genomics, proteomics, and imaging have allowed monitoring of these effects and provide new cUrecdves for the future. All together, we provide a balanced review for the role of immunity in the pathogenesis of PD and ALS and the means to modulate it for therapeudc benefit. The sdengths and concerns for each of these approaches are discussed. 

Rdpdm Cin VatjCtie Therapy AnliboctiRf scFv Irirebodics 

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