Paraoxon plasma treatment

UV/ozone treated parathion and paraoxon samples (treatment time = 5 min) were still toxic enough to kill all Drosophila in less than 12 hours in the culture bottle. In contrast, the Drosophila in the bottle containing the plasma-treated sample (treatment time = 10 sec) lived their full life cycle and laid eggs. Even the newly hatched larvae were able to develop into adult flies. These culture test results qualitatively demonstrate the efficacy of the atmospheric if plasma process for the complete decomposition and detoxification of OP nerve agents. 

It was reported that in parathion poisoning, an obi-doxime dose of 250 mg intravenously administered as a bolus followed by infusion of 750mg/day was effective, but AChE reactivation after severe poisoning did not occur until the concentration of paraoxon in plasma became low (Thiermann et al., 1997,1999). Oxydemeton methyl poisoning responded to obidoxime therapy only when the oxime was instituted soon after poisoning. In cases when obidoxime treatment was started too late, there was no reactivation of erythrocyte AChE and one out of six patients died. 

---