Paralogs identifying

Detailed analyses of expansions of paralogous proteins are important not only from a diagnostic perspective (identifying members of gene families unique to specific organisms), but also from a therapeutic perspective (developing vaccines and... 

As illustrated in Figure 2.2-1, dysbindin-3 consists of an NTR and a CTR made up of the DD and X segments 1 and 2. This paralog has no clear PEST domain as discussed in Section 2.2.33.2. Dysbindin-3 differs from both dysbindin-1 and -2 in several ways identified in Section 2.2.2.2.2. 

Morgan, R., In der Rieden, P., Hooiveld, M.H., Durston, A.J. 2000. Identifying HOX paralog groups by the PBX-binding region. Trends Genet. 16, 66-67. 

As a further semantic complication, recent work has identified a rihoflavin synthase type in Archaea that is paralogous to lumazine synthase. This unexpected finding will he described in more detail in the chapter on rihoflavin synthase. 

The HD AC family of proteins plays a critical role in modulating chromatin structure and in regulating the functions of other proteins. Several HDAC inhibitors are used in clinical trials as anticancer drugs. However, these inhibitors are not selective among the multiple HDAC paralogs that have been identified. Thus, new selective inhibitors are required to separate the functions of the various HDAC family members. In particular, treatment with pan-HDAC inhibitors also results in hyperacetylation of a-tubulin, the functional implications of which are unclear. 

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