Paracetamol assay

Unknown Bulk Material A container-load of Paracetamol (10 MT) arrives at a raw-material stores and the composition of the bulk material is unknown, it will be a sensible and logical practice to carry out first and foremost a preliminary investigation by collecting a large number of samples and assaying the analyte of interest. [Pg.88]

A.D. Trafford, R.D. Jee, A.C. Moffat and P. Graham, A rapid quantitative assay of intact paracetamol tablets by reflectance near-infrared spectroscopy, Awa/yrf, 124, 163-168 (1999). [Pg.278]

A.C. Moffat, A.D. Trafford, R.D. fee and P. Graham, Meeting of the International Conference on Harmonisation s guidelines on vahdation of analytical procednres Qnantiflcation as exemplified by a near-infrared reflectance assay of paracetamol in intact tablets. Analyst, 125, 1341-1351 (2000). [Pg.488]

Standard operating procedure (SOP) for the assay of paracetamol tablets... [Pg.2]

An estimate of compound random errors is obtained from the square root of the sum of the squares of the RSDs attributed to each component or operation in the analysis. If the analysis of paracetamol described in Box 1.3 is considered then, assuming the items of glassware are used correctly. Assuming the items of glassware are used correctly the errors involved in the dilution steps can be simply estimated from the tolerances given for the pipette and volumetric flasks. The British Standards Institution (BS) tolerances for the grade A glassware used in the assay are as follows ... [Pg.11]

Assay of paracetamol and aspirin in tablets using a narrow range calibration curve... [Pg.237]

Amount of paracetamol found in the tablet powder assayed = 126,6 mg. [Pg.255]

Amount of paracetamol expected in the tablet powder taken fpr assay... [Pg.255]

The assay is more or less the same as that described for the paracetamol tablets except that the tablets are extracted with 0.05 M sodium acetate buffer pH 4.4. The calibration standard solutions are prepared so that they contain both aspirin and paracetamol in 0.05 M sodium acetate buffer pH 4.4 in the concentration range 1.0-1.5 mg/100 ml. [Pg.256]

Trafford, A.D. Jee, R.D. Moffat, A.C. 8t Graham, P., A Rapid Quantitative Assay of Intact Paracetamol Tablets by Reflectance Near-Infrared Spectroscopy Analyst 1999, 124, 163-168. [Pg.224]

Smith, M.R., Jee, R.D. and Moffat, A.C. (2002) The transfer between instruments of a reflectance near-infrared assay for paracetamol in intact tablets Analyst 127, 1682-1692. [Pg.388]

X. G. Fang, P. Shen, and S. Ghodbane, Mixed ion pair liquid chromatography method for the simultaneous assay of ascorbic acid, caffeine, chlorpheniramine maleate, dextromethorphan HBr monohydrate and paracetamol in Frenadol sachets, J. Pharm. Biomed. Anal., 72 85 (1994). [Pg.233]

N. Zhang and Y. Yu, Assay of compound paracetamol tablets by HPLC, Yaowu Fenxi Zazhi, 5 99(1985). [Pg.256]

Argekar and Sawant [55] developed simultaneous determination of paracetamol and mefenamic acid in tablets by high performance thin layer chromatography method (HPTLQ. The procedure was performed on silica gel using toluene-acetone-methanol (8 1 1) as the solvent system. Detection and quantification of the substance was assayed by densitometry at 263 nm. The linearity ranges were 120-360 ng/pL and the RSD were between 0.41 and 0.78%. Limit of detection and limit of quantification were found to be 1.80 and 5.5 ng/pL, respectively. Recoveries were in the range of 95.50-103.60%. [Pg.304]

Jensen, L.S., Valentine, J., Milne, R.W., Evans, A.M. The quantification of paracetamol, paracetamol glucuronide and paracetamol sulphate in plasma and urine using a single high-performance liquid chromatography assay. J. Pharm. Biomed. Anal. 24, 585-593 (2004)... [Pg.278]

Hewala II. Stability-indicating HPLC assay for paracetamol, guaiphenesin, sodium benzoate and oxomemazine in cough syrup. Anal Lett 1994 27 71-93. [Pg.249]

In Norway, Wieders Farmasoytiske A/S received approval for the use of NIR as an alternative method for identification, assay, and determination of moisture content of paracetamol (acetaminophen) tablets. The Norwegian Medicines Control Authority approved the method in December 1996. [Pg.3632]

Merckle and Kovar reported an assay of effervescent tablets (intact and powdered) by NIRS in transmittance and reflectance modes. Results of quantitative determination of acetylsalicylic acid (ASA) and ASA in combination with ascorbic acid and/or paracetamol were comparable in both transmittance and reflectance modes. Corti and associates described a NIR transmittance analysis of coated tablets, using both whole and milled tablets. [Pg.3636]

In cases of suspected benorilate overdosage, both salicylate and paracetamol should be assayed. [Pg.420]

Morris HC, Overton PD, Ramsay JR, Campbell RS, Hammond PM, Atkinson T, et al. Development and validation of an automated enzyme assay for paracetamol (acetaminophen). Clin Chem Acta 1990 187 95-104. [Pg.1362]

Al-Obaidy, S.S. Po, A.L.W. McKiernan, P.J. Glasgow, J.F.T. Millership, J. Assay of paracetamol and its metabolites in urine, plasma and saliva of children with chronic liver disease. J.Pharm. Biomed.AnaL, 1996, 13, 1033-1039... [Pg.8]

Indrayanto, G. Sunarto, A. Adriani, Y. Simultaneous assay of phenylpropanolamine hydrochloride, caffeine, paracetamol, glycerylguaiacolate and chlorpheniramine in Silabat tablet using HPLC with diode array detection. J.Pharm.Biomed.Anal., 1995,13, 1555-1559... [Pg.11]

Akhtar, M.J. Khan, S. Hafiz, M. High-performance Liquid chromatographic assay for the determination of paracetamol, pseudoephedrine hydrochloride and triprolidine hydrochloride. J.Pharm. BiomedAnal., 1994, 12, 379—382 [simultaneous pseudoephedrine, triprolidine formulations]... [Pg.21]

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