Pancreas, lung, colorectal

Parameter log GI50 Pancreas Breast CNS Lung Colorectal Prostrate... 

Kleif et al. J Immunother, 1999 I Detox Ras Colorectal, pancreas, lung CTL, PR... 

Parameter GI50 BxPC-3 Pancreas MCF-7 Breast SF-268 CNS H460 NSC Lung KM20L2 Colorectal DU-145 Prostrate... 

Primary adenocarcinomas of the lung are typically CK7-F, CK20-, and CEA-f, whereas colorectal carcinomas are CK7-, CK20-F, and CEA-i- ductal and lobular breast carcinomas are CK7-f, CK20-, and often CEA-I- and ovarian carcinomas are CK7-I-, CK20 , and CEA-.121,125-129,224-227 Neoplasms that typically are strongly positive for most CEA antibodies include adenocarcinomas of the lung, colon, stomach, biliary tree, pancreas, urinary bladder, endocervix, paranasal... 

Another area worthy of future investigation is the treatment of non-colorectal, non-neuroendocrine cancers metastatic to the liver. Often referred to as mixed neoplasia, these refer to patients with liver-dominant metastatic disease to the liver from various primaries (breast, melanoma, pancreas, and lung). Although several reports have been described, controlled phase II studies using time-to-progression, tumor response, or progression-free-survival would be clinically relevant given the dearth of options for some of these patients [51-54]. 

Primary and secondary malignant hepatic tumors are a major health problem worldwide. While metas-tases are common in western countries, primary liver cancers are frequently diagnosed in Asia and Africa. However, recent data suggest that the incidence and mortality of hepatocellular carcinoma (HCC) in Western nations are on the rise (Taylor-Robinson et al. 1997 Llovet et al. 2003). Likewise, the liver is the most common site for metastases. In 25%-50% of patients with malignancies liver metastases were observed at autopsy (Bernardino et al. 1982). The most frequent primary sites are colon, breast, pancreas, and lung. In the case of colorectal metastatic disease, the liver is the only metastatic site in 20%-30% of patients (Sasson and Sigurdson 2002). 

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