2-PAMI

Synonyms. PAM P-2-AM 2-PAM Iodide 2-PAMI Pamium Pyraloxime Iodide 2-Pyridine Aldoxime Methiodide. 

Percutaneous (single dose 5-45 g/kg) 22 subjects Oral (multiple dose) 29 subjects Treatment (23 subjects 2-PAMi Atropine, Regltlne Route intravenous (1.2 - 2.0 Mg/kg) 7 subjects... 

In three studies reviewed by FAO/WHO (1994) on phosalone and 2-PAM methylsulfate in mice, P2S in rats, and obidoxime in mice, all appeared effective, although various aspects of the design of the. studies were not optimal. Oximes (PAM or obidoxime) in combination with atropine were successful in rats experimentally poisoned with pyrazophos, and there was some indication that repeated dosing was required for optimal antidotal efficacy (FAO/WHO, 1993). In a rat study of experimental terbufos poisoning, little benefit was observed from PAM and atropine (FAO/WHO, 1991). In rat studies on triazophos, combinations of atropine. sulfate and 2-PAMI or atropine sulfate and obidoxime were successful as experimental therapies (FAO/WHO, 1994). The effects of oximes in profenofas-poisoned chicks and mice were reported to be limited, as expected, although atropine was effective (FAO/WHO, 1991). 

In the mid 1950s, Wilson and coworkers reported that hydroxamine reactivated organophosphoryl-inhibited ChE faster than water did,134 and later reported that an oxime (pyridine-2-aldoxime meth-iodide [2-PAMI]) was far more effective than hydroxamine in reactivating the enzyme.135... 

Mallat, S. G., A theory for multiresolution signal decomposition The wavelet representation. IEEE Trans. Pattern Anal. Mach. Intell. PAMI-1K7), 674-693 (1989). 

Interestingly, for the transformation of both the racemic 1-hydroxyalkanephosphonates 41 and 2-hydroxyalkanephosphonates 43 into almost enantiopure acetyl derivatives 42 and 44, respectively, a dynamic kinetic resolution procedure was applied. Pamies and BackvalP used the enzymatic kinetic resolution in combination with a ruthenium-catalysed alcohol racemization and obtained the appropriate O-acetyl derivatives in high yields and with almost full stereoselectivity (Equation 25, Table 5). It should be mentioned that lowering... 

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