Palmitoyl-functionalized poly

Figure 11.44 (Left) Structures of photoresponsive poly (propylene imine) dendrimers. (Right) The isomerization behavior of palmitoyl-functionalized amphiphilic dendrimers at the water surface.

Figure 14.1 Molecular stmcture of cholesteiyl-, palmitoyl- or cetyl-functionalized poly(allylaimne)s.

Uchegbu and coworkers have studied the complexation and delivery of DNA using a unique poly(amino acid)-based polymer vesicle. A polymer of either poly (L-lysine) or poly(L-omithine) was functionalized with methoxy-poly(ethylene glycol) (mPEG) and hydrophobic palmitic acid chains to synthesize an amphiphilic triblock of either mPEG-6-poly(L-lysine)-6-palmitoyl or mPEG-Z>-poly(L-omithine)-6-palmitoyl. Vesicles formed from these polymers were complexed with DNA and showed improved transfection in vitro over poly(amino acid) complexed with DNA or DNA alone [82]. 

Poly(propyleneimine) dendrimers functionalized with hydrophobic alkyi chains (palmitoyl chains or alkyloxyazobenzene chains) assembled into stable monolayers at the air-water interface [157,257]. In the assemblies, the dendrimers adopt a cylindrical, amphoteric shape, in which the ellipsoidal... 

Poly(propylene imine) dendrimers functionalized with hydrophobic alkyl chains (palmitoyl chains or alkyloxyazobenzene chains) assembled into stable monolayers at the air-water interface [122,180]. In the assemblies, the dendrimers adopted a cylindrical amphoteric shape in which the ellipsoidal dendritic moiety acted as a polar head-group and the alkyl chains arranged in a parallel fashion to form an apolar tail (Fig. 33b). This representation is based on the observation that the molecular area of a dendritic molecule increases linearly with the number of end-groups in this molecule. 

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