Pallidine

Corydalis incisa (Thunb.) Pers. C. bungeana Turcz. Chuan Duan Chang Cao Di Ding Zi Jing (Corydalis) (whole plant) Protopine, pallidine, sinocecatine, corynoline, isocorynoline, coptisine, corycavine, acetylcorynoline, corynoloxin, coreximine, reliculine, corydamine, scoulerine.33,50 For rectal prolapse, abscesses, hemorrhoids. 

New bases that have been isolated are represented by norpallidine (124 R = H), from Fumaria vaillantii, identified by its Eschweiler methylation to pallidine (124 R = Me).147 Pallidine has been shown to be produced (together with coreximine,... 

Reticuline has been biotransformed into the morphinandienone pallidine, the aporphine isoboldine, and the protoberberines coreximine and scoulerine by rat liver enzyme 37 and the use of isolated enzymes in the formation of natural products, including aporphines, has been reviewed.38... 

Pallidin Q9UL45 (h) Syntaxin 13-interacting protein PLDN (h) 15q21.1 (h)... 

Localization of dysbindin-1 near the sarcolemma is not dependent upon its association with a-dystrobrevin or myospryn. Benson et al. (2001) found that sarcolemmal levels of dysbindin-1 are increased in the mdx mouse, an animal model of Duchenne muscular dystrophy. Yet mdx mice also display decreased sarcolemmal levels of a-dystrobrevin (Benson et al., 2001) and myospryn (Reynolds et al., 2008). The sarcolemmal association is more likely due to other known or candidate-binding partners of dysbin-din-1, specifically pallidin, snapin, and rab 11, which are all increased along with dysbindin-1 in mdx muscle (Nazarian et al., 2006). But the increases in pallidin and dysbindin-1 are not related to muscular dystrophy since there are no apparent abnormalities in the muscles or motor behavior of pallid mice (Nazarian et al., 2006), which are deficient in pallidin and dysbindin-1 (Li et al., 2003). 

Loss of BLOC-1 proteins following loss of individual BLOC-1 components as shown by Li et al. (2003) in kidney extracts. The loss of dysbindin-1A in homozygous sdy (sdy/sdy) mice is accompanied by loss of muted and a major reduction in pallidin. Loss of muted in mice homozygous for a deletion mutation in Muted (mu/mu) is similarly accompanied by loss of dysbindin-1A and a major reduction in pallidin. Likewise, loss of pallidin in mice homozygous for a deletion mutation in Pallid (pa/pa) causes loss of muted and reduction in dysbindin-1. To a lesser extent, the same phenomenon occurs in mice homozygous for a deletion mutation in another BLOC-... 

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