Palladium complex organic molecules synthesi

B. M. Trost, Acc. Chem. Res., 1980, 13, 385 J. Tsuji, Tetrahedron, 1986, 42, 4361 L. S. Hegedus, Transition Metals in the Synthesis of Complex Organic Molecules, 2nd ed., University Science Books Sausalito, CA, 1999, pp. 250-282 and J. Tsuji, Palladium Reagents and Catalysts, Wiley Chichester, England, 2004, Chap. 4. 

Palladium-catalyzed C-C cross-coupling reactions belong to the most important types of catalytic carbon-carbon bond-forming reactions and are nowadays an indispensable tool for the target-oriented synthesis of complex organic molecules across aU research fields and industrial segments. Various types of palladium... 

S. (1999) Palladium in action domino coupling and atlylic substitution reactions for the efficient construction of complex organic molecules. J. Organomet. Chem., 576, 88-110 (d) Chapman, C.J. andProst, C.G. (2007) Tandem and domino catal3dic strategies for enantioselective S3mthesis. Synthesis, 1-21. 

Mizoroki and Heck first reported their independent discoveries of palladium(0)-catalysed vinylations of aryl halides over 30 years ago [1], This transformation, now known as the Mizoroki-Heck reaction, can be broadly defined as the palladium(0)-mediated coupling of an aryl or vinyl halide (or triflate) with an alkene. The potential utility of this transformation in complex molecule synthesis was largely unappreciated for a number of years however, its application for the construction of complex organic molecules, including natural products, has flourished recently [2],... 

The Strychnos alkaloids possess diverse chemical structures that have attracted considerable attention in organic synthesis during the last decades. Recent studies on the synthesis of akuammicine, strychnine and leuconicine A and by Andrade et al. proved that the intramolecular Heck reaction is extremely valuable for the construction of complex polycyclic molecules. Based on Rawal s method for the construction of the D ring of Strychnos alkaloids, vinyl iodides 37, 39, and 42 undergo a regioselective and stereoselective palladium-catalyzed cychzation in the presence of Pd(OAc)2, PPha in Et3N to furnish ( )-akuammi-cine 38, and the advanced intermediates 40 and 43 in excellent chemical yields (Scheme 13.11). 

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