PAF-antagonism

Interestingly, moderate PAF antagonism has also been reported for a series of 1,4-dioxanes, of which (12) is representative [111]. 

Recent research on lignans has focused on a range of compounds demonstrating cardiovascular activities such as inhibition of cyclic AMP phosphodierstase, PAF antagonism, calcium channel antagonism and antihypertensive and antioxidant effects (Ghisalberti et al. 1997). 

Other recently reported activities of schisandra fruit include reduced proteoglycan degradation (antihyaluronidase activity) and antiplatelet activation (PAF antagonism). ... 

The studies carried out so far clearly demonstrate that the effect on Gly receptors is distinct from the effect on PAF receptors, as SAR studies have shown that the structural requirements are different for the two receptors. The potential importance of the antagonism of Gly receptors also remains to be investigated. 

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