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Packaging of Viral Genomes

Cross-packaging is the packaging of viral genomes into the virion shell of other viruses. [Pg.397]

Johnson, J. E., and Rueckert, R. R. (1997). Packaging and Release of Viral Genomes. Oxford University Press, Oxford. [Pg.254]

Thus, the process of viral genome packaging is a conflict of scales, wherein a long molecule must be compressed within a length scale on which it resists bending and to a monomer density at which it must also overcome strong repulsive forces from electrostatic and excluded volume interactions. Such a conflict... [Pg.323]

The gag, pol, and env genes of the retroviral genome, required for retroviral replication and assembly of viral particles, can be replaced with foreign DNA. To assemble viruses that contain the recombinant genetic information, researchers must introduce the DNA into cultured cells that are simultaneously infected with a helper virus that has the genes to produce viral particles but lacks the [Pg.334]


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Viral genome

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