Pabo, Carl

The x-ray structure of the N-terminal DNA-binding domain of the lambda repressor was determined to 3.2 A resolution in 1982 by Carl Pabo at Harvard University and revealed a structure with striking similarities to that of Cro, although the p strands in Cro are replaced by a helices in repressor. 

It has also been possible to determine the x-ray structures of classic zinc finger motifs from several proteins bound to specific DNA fragments. We will here describe one such structure containing three zinc fingers from a mouse protein, Zif 268, which is expressed at an early developmental stage of the mouse. Nikola Pavletich and Carl Pabo at the Johns Hopkins University School of Medicine, Baltimore, determined the x-ray structure to 2.1 A resolution of a recombinant polypeptide derived from Zif 268 bound to a 10-base... 

J. Keith Joung, Elizabeth I. Ramm and Carl O. Pabo, A bacterial two-hybrid selection system for studying protein-DNA and protein-protein interactions. Proceedings of the National Academy of Sciences USA, 97 (2000), 7382-7387. 

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