P-Glucuronic acid

Mammalian metabolism studies on sampangine gave two water-soluble conjugates. One of those conjugates, SAM MMl, has been identified as sampangine-P-glucuronic acid. 

Hyaluronic acid Animal (synovial fluid, vitreous humour of the eye, umbilical tissue microbial (fermentation Bacillus subtflis) P-glucuronic acid and N-acetyl-P-glucosamine (GlcNAc) linked by a-(l/3) bond. [35]... 

GeUan gum as a repeating unit Microbial (bacterium Sphingomonas elodea) Tetrasaccharide, (l/4)-Lrhamnose--(l/3)-P-glucose—(1 /4)-P-glucuronic acid—(l/4)-d-glucose [37]... 

A.- ng deduction. This is an irreversible reaction which is a foremost determinant of the secretion rate of cortisol (double bonds and C-3 carbonyl). Catalyzed predominantiy by cortisone P-reductase and 3a-hydroxysteroid dehydrogenases, SP sterols result, although 5a sterols are more prevalent in the case of other glucocorticoids. Urocortisol and urocortisone result from the metabohsm of cortisol and cortisone, respectively. Compounds can be complexed to glucuronic acid at this point. 

P -D-xylan with 3-hnked a-L-arabiaose branches (1 4)-P -D-xylan with 2-Unked 4-0-methyl-a-D-glucuronic acid and arabiaose branches... 

Xanthan (Figure 11) is a commercially important polysaccharide produced by the bacterium Xanthomonas campestris.187 188 The xanthan backbone consists of a P(l-4)-linked D-glucopyranose chain with a trisaccharide side chain attached at C3 to alternate glucose residues. These side chains consist of an acetylated mannose residue, a glucuronic acid residue, and a pyruvate ketal linked to a terminal mannose residue. The acetate and pyruvate content depend on the fermentation and isolation conditions used by the supplier. 

UDP-glucuronyltransferases catalyze the addition of glucuronic acid onto phenol, hydroxyl and carboxylic acid functions of molecules. They are expressed in many tissues of the body, including the liver and intestine [2-5], Microsomes from human intestines have been shown to metabolize UDP-glucuronyltransferase substrates including p-nitrophenol [6], 1-naphthol, morphine, and ethinylestradiol [4]. The relative rates of metabolism of these substrates in liver and intestinal microsomes are shown in Table 13.1. 

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