P-Glucosidase inhibitor

S. Atsumi, K. Umezawa, H. Iinuma, H. Naganawa, H. Nakamura, Y. Iitaka, and T. Takeuchi, Production, isolation and structure determination of a novel P-glucosidase inhibitor, cyclophellitol, from Phellinus sp, J. Antihiot., 43 (1990) 49-53. 

T. M. Wrodnigg, S. G. Withers, and A. E. Stiitz, Novel, lipophilic derivatives of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) are powerful p-glucosidase inhibitors, Bioorg. Med. Chem. Lett., 11 (2001) 1063-1064. 

C-butyl-DMDP good P-glucosidase inhibitor and poor inhibitor of P-galactosidase ... 

Chemical structure and biological activity of a- and p-glucosidase inhibitors 06T10277. 

The readily available 2,3 6,7-di-0-isopropylidene-D-g/> cero-D-gM/o-heptano-1,4-lactone has been converted into the iminooctitol 45 as a potential galacto-sidase inhibitor, but in practice was found to be a good P-glucosidase inhibitor. ... 

Cyclitols and Derivatives. - A review on the application of the Pd(II)-catalysed Ferrier (II) carbocyclization in the synthesis of p-glucosidase inhibitors, cyclophellitol, all the diastereoisomers of inositol, and D-myo-inositol phosphates has been published. ... 

Tatsuta K, Niwata Y, Umezawa K, Toshima K, Nakata M (1990) Enantiospeciiic total synthesis of a p-glucosidase inhibitor, cyclophellitol. Tetrahedron Lett 31 1171-1172... 

A total synthesis of the natural product cyclophellitol, 38, a P-glucosidase inhibitor, has been described starting from >-glucose, in which the key transformations are Fenier rearrangement of 35 and a stereoselective epoxidation of 37 (Scheme 10). The natural product (-)-ovalicine 39, another epoxy cyclohexane, has been prepared from the cyclitol L-quebrachitol (Scheme 11). ... 

The synthesis of a glucose-derived tetrazole as a new P-glucosidase inhibitor as well as a synthesis of deoxynojirimycin have been reported (Scheme 10)/ ... 

The synthesis of D-gluconohydroximino-1,5-lactam and its analogues as P-glucosidase inhibitors is covered in Chapter 9. 

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