P-bromo-a-hydroxy acids

ASYMMETRIC SYNTHESIS OF (S)-a-SUBSTmJTED P-BROMO-a-HYDROXY ACIDS... 

S)-a-substituted P-bromo-a-hydroxy acids (S)-4 are very important chiral synthon for medicinally important compounds, such as potential new hypoglycemia active alkylglycidic acids (ref. 1) and anti-ulcer active misoprost (ref. 2). 

Scheme 1. Asymmetric synthesis of (S)-a-substimted P-bromo-a-hydroxy acids...

R) -a-methyl P-bromo-a-hydroxy acid, (S) (-)-4a, as a white solid (603 mg, yield 91 %) showing 97 % ee (ref. 6). The 2h, 2c and 2d were treated in the same manner as 2a to give the corresponding (S)-a-substituted P-bromo-a-hydroxy acids ... 

---

See also in sourсe #XX -- [ ]

---