P-Aminopropionitrile

The biochemical problem has been traced to the presence in the seeds of P-cyanoalanine and of its decarboxylation product P-aminopropionitrile. 

Aminomutases (vitamin B12) 872, 874 8-Amino-7-oxo-nonanoate 718, 742 Aminopeptidase(s) 117, 609, 627 p-Aminopropionitrile 438 Aminopterin, inhibition of dehydrofolate reductase 805... 

Direct reaction of hydrocyanic acid with ethyleneimine does not yield the desired p-aminopropionitrile (68). However, ring opening of tosylated aziridines to give the corresponding tosylated p-aminopropionitriles is possible using trimethylsilyl cyanide [7677-24-9] with lanthanoid tricyanide catalysis (69,70). 

AxMINOPROPIONITRILE see AMB500 P-AMINOPROPIONITRILE see AMB500 P-AMINOPROPIONITRILE FUMARATE see AMB750 p-AMINOPROPIOPHENONE see AMCOOO... 

The skeletal and vascular form of lathyrism (odoratism) produced by feeding sweet peas (Lathyrus odoratus) or p-aminopropionitrile (SIS) bears certain resemblances to scurvy. Only a single observation is recorded about any possible connection. The production of odoratism in rats was not modified by feeding them 12 mg ascorbic acid daily (LIO). 

Lathyrinogenic amino acids nonproteogenic amino acids occurring in the seeds of some species of vetch (Lathyrus). They include diaminobutyric acid H2N-(CH2)2-CH(NH2)- 00H (neurolathrinogenic effect), p-aminopropionitrile, which occurs as the glutamyl peptide in the seeds of Lathyrus. odoratus, and presumably the N-oxaloyl-a,p-diamino-propionic acid HOOC-CH(NH2)CH2-NH-CO-COOH. The disease caused in humans and animals by L.a.a. is called lathyrism, and takes various forms, e.g. neuro-(nerve)- and osteo(bone)-lathyrism e.g. PiAiy-gluta-rayI)aminopropionitrile causes skeletal abnormalities in rats... 

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