P450 enzymes nomenclature

Allele nomenclature for Cytochrome P450 enzymes. Available at http //www.cypalleles. ki.se. 2008. Accessed March 28, 2008. 

Nelson DR, Kamataki T, Waxman DJ, et al. The P450 superfamily update on new sequence, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Bioi 1993 12 1-51. 

The cytochrome P450 system is the principal enzyme system for the metabolism of lipophilic xenobiotics. It is a heme-containing, membrane-bound, multi-enzyme system which is present in many tissues in vivo but is present at the highest level in liver. A coenzyme, cytochrome P450 NADPH oxidoreductase (OR), is essential for P450 catalytic function and cytochrome bs may stimulate catalytic activities of some enzymes. In human liver, it is estimated that there are 15-20 different xenobiotic-metabolizing cytochrome P450 forms. A standard nomenclature, based on relatedness of the amino acid sequences, has been developed (Nelson et al., 1993). The most recent... 

Nelson, D.R., Kamataki, T., Waxman, D.J., Guengerich, F.P., Estabrook, R.W., Feyereisen, R., Gonzalez, F.J., Coon, M.J., Gunsalus, I.C., Gotoh, O., Okuda, K., and Nelson, D.W., The P450 superfamily update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature, DNA Cell Biol., 12, 1-51, 1993. 

Fig. 5. Nomenclature system for designating enzymes and alleles of cytochrome P450. From Linder MW, Valdes R Jr. Pharmacogenetics fundamentals and applications. Therapeutic drug monitoring and toxicology. AACC 1999 20(l) 11 with permission.)...

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