Oxytocin oxytocic activity

BMY 40900 Videx ) is a synthetic reverse transcriptase INHIBITOR, active as an ANTIVIRAL and used in anti-hiv treatment. It is mainly administered to patients who are intolerant to. or have not benefited from, zidovudine, didehydroproline oxytocin ((t -Pro joxytocin) is an analogue of oxytocin and an agonist at oxytocin receptors (i.e. an (OT) VASOPRESSIN RECEPTOR AGONIST) with greater OXYTOCIC activity than oxytocin. 

AVP), except in the pig which has a Lys residue (iysine vasopressin). Oxytocin differs from vasopressin in having leucine at position 8 and isoleucine at position 3. Vasopressin and oxytocin analogues with some degree of receptor subtype selectivity that have been synthesized have ANTIDIURETIC or vasoconstrictor or OXYTOCIC (uterine-contracting) activity. See VASOPRESSIN RECEPTOR AGONISTS VASOPRESSIN RECEPTOR ANTAGONISTS. 

The biological activity of the peptides is compared to that of the third international standard established in 1957. The international standard is an acetone powder of ox pituitaries. Its activity is defined in units. One unit is the activity exhibited by 0 5 mg of the dry powdered material 1 mg of pure synthetic oxytocin has an oxytocic potency of 450 international units (lU) 1 mg of pure synthetic arginine -vasopressin has a pressor potency of 400 lU. 

Leu2, Leu ]oxytocin, which has natriuretic activity and weak diuretic effects, is also an inhibitor of oxytocic activltyl in contrast to [Leu ]oxytocin which has considerable diuretic and natriuretic effects as well as anti-ADH activity (inhibiting the antidiuretic effect of vasopressin) other 4-substituted oxytocins have been reported to have anti-ADH... 

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