Oxytetracycline Analytical Profile

Assessment Service Unit, Faculty of Pharmacy, Airlangga University, Dharmawangsa Dalam, 

Oxytetracycline is available as oxytetracycline (C22H24N2O9 MW 460.4) [1-3], oxytetracycline hydrochloride (C22H24N2O9HCI MW 496.9) [1,2,4-8], oxytetracycline dihydrate (C22H24N2O9 2H2O MW 496.4) [1,2], and oxytetracycline calcium 

PROFILES OF DRUG SUBSTANCES, EXCIPIENTS, AND RELATED METHODOLOGY, VOLUME 32 ISSN 0099-5428 

Molecular structure. The molecular structure of oxytetracycline is as follows  

Oxytetracycline occurs as yellow crystals or crystalline powder, has a bitter taste and is odorless. Oxytetracycline hydrochloride should have potency not less than 835 pg C22H24N2O9 per mg [1], whilst for oxytetracycline not less than 832 pg/g [1] or 95.0-102.0% as anhydrous substance [2] or not less than 88.0% of C22H24N2O9 calculated as anhydrous basis [3,4]. For oxytetracycline calcium, it should contain not less than 90.0% and not more than 100.5% [2], or 865 pg C22H24N2O9 per mg [1]. Oxytetracycline was produced by the growth of certain strain of Streptomyces rimosus or obtained by other means. 

---