Oxygen sensing system

Amao, Y., Asai, K., and Okura, I. (2000). A novel optical oxygen sensing system based on triplet-triplet reflectance of fullerene Cgg-polystyrene film by time-resolved spectroscopy using diffuse reflectance laser flash photolysis. Analyst, 125, 523-fi. 

Optical Oxygen-Sensing Systems Based on Triplet-Triplet Absorption of Organic Dye... 

A prolyl hydroxylase-based oxygen-sensing system fits well with key attributes of the HIF system— notably that iron chelators or cobaltous ions mimic the effect of hypoxia. In particular, iron chelators remove the ferrous iron atom from the active site of the enzyme, preventing the conversion of HIF alpha subunits and thereby mimicking hypoxia. Exposure to cobaltous ions results in substitution of cobalt for the iron at the active center, also disabling the enzyme. Thus, the prolyl hydroxylase sensor accommodates the effects of cobalt and iron chelators without requiring the sensor itself to be turning over rapidly. 

The other above-mentioned sensing system relies on measurement of carbon dioxide (rather than oxygen) produced in the biochemical reaction of L-glutamate catalysed by glutamate decarboxylase (GDC) ... 

The oxygen sensing properties of such electrode systems were measured at first. The reproducibility of the output current versus oxygen tension is shown in Figure 2. The coefficient of correlation was 0.987 using eighteen data points. 

The majority of Os(II) complexes exhibit weak luminescence and might not appear to be attractive candidates for use in various sensing schemes based on luminescence. Systems serving as oxygen sensors, including Os(II) complexes, have recently been reviewed [105]. Nonetheless, there are a few recent examples of applications of this sort and one recent application of a Ru(II)/Os(II) energy transfer based sensing system. 

Acute high-altitude studies of both human and animal models indicate that hypoxia defenses are initiated by several oxygen sensing, signal transduction pathways. For convenience, these have been summarized as five general hypoxia response systems (figure 5.2(A)-(E) ... 

In closed systems, or in systems to which the flux of oxygen is restricted, respiration brings about changes in oxygen tension, which makes the process accessible to measurement by appropriate sensing systems [57]. 

Andreescu et al. introduced a 96-electrode well-type device enabling oxygen sensing for monitoring respiratory activity of biological cells.65 65 The principal set-up of the multichannel dissolved oxygen sensor system (DOX-96) is schematically in shown in Fig. 14.13. This highly parallelized approach shows successful... 

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